When U.S. Sen. Edward Kennedy was diagnosed with a glioblastoma of the brain in May 2009, doctors understood there was little chance he could survive it. He died that August.
Thats a malignant tumor. The current five-year survival rate is 1 percent, says Ricardo Komotar, a neurooncologist at Sylvester Comprehensive Cancer Center.
But cancer specialists from the University of Miami Medical School and nine other U.S. institutions are well into clinical experiments aimed at ending the tumors fatal reputation.
Were not going to cure it, says Komotar, who is also director of surgical neurooncology at UM Hospital. Our goal is to convert it into a chronic condition like high blood pressure or diabetes that you can live the rest of your life with and live a very normal life.
Their weapon: a brain cancer vaccine. Its not a preventive vaccine like a flu or polio shot, given to ward off disease. Instead, its a therapeutic vaccine given after the patient already has the tumor. Its still called a vaccine because, unlike most cancer medicines, it doesnt attack the disease directly. Instead, it marshals the bodys own immune system to attack it.
This is the future of cancer therapy, Komotar says. Radiation and chemotherapy fight the cancer but they also kill normal cells, and theyre toxic. This kills the cancer without harming normal tissue.
Sheryl Shetsky, president of the Florida Brain Tumor Association, said the research is important because glioblastomas are 30 percent of all brain tumors, and theyre the most devastating tumor. Youre still going to want radiation and chemo for others cells you cant see. But this can buy the patient a lot more time.
The new vaccine is given quickly after a patients glioblastoma is diagnosed, Komotar says before surgery, chemotherapy or radiation because doctors need to use the excised tumor to make the vaccine.
In the treatment, surgeons remove the malignant tumor, then isolate and concentrate essential proteins from it and inject them back into the patients arm six to eight weeks later. The patients immune system recognizes the proteins as invaders, and produces billions of T-cells, its natural attack system, to fight it.
It really sparks the immune system; it gives it a target, Komotar says. Lots of work remains to be done, but it is a step in the right direction.
Developed about five years ago at the University of California at San Francisco, the vaccine did so well in Phase I clinical trials for safety that it now has U.S Food and Drug Administration approval to begin Phase II trials for efficacy.
Even in the Phase I trials, it greatly extended the life expectancy of volunteers, Komotar says.
To read the complete article, visit www.miamiherald.com.